Technology

Advanced ophthalmic camera

We’ve invented a new optical imaging method combining transscleral flood illumination of the retina with adaptive optics (AO-TFI). The method allows the observation of several eye structures at cellular level that are invisible with regular transpupillary illumination. It makes possible the quantitative measurement of structures affected early in diseases, such as retinal pigment epithelium.

Cellular resolution image

RPE cells visualization

Large field fundus overview

Benefits

Cellularis Discovery provides images that are 10 times more detailed than the standard instruments used in hospitals. Its spectacular precision is achieved while providing a great user experience. Indeed, a quick acquisition time together with manual joystick operation enable simple and familiar examination process for both patient and operator. Moreover, infrared lateral and transpupil illumination is very comfortable for the patient.

Times more precise

Seconds acquisition time

Degrees single cellular image field

Look at tissue details

As opposed to standard instruments, our optical technology allows the observation of microscopic structures in the eye. The ideal tool to catch the first impacts of tissue degenerative processes.

What we can achieve

Cellularis Discovery makes visible important retinal cells and structures, such as retinal pigment epithelium (RPE), retinal nerve fibre layer (rNFL), retinal blood vessels and photoreceptors (PR). These biological structures play key roles in several eye diseases. It is the perfect tool to investigate the retina anatomy and the pathological processes. Research doctors and biotech companies see the potential to better understand eye conditions as well as assessing new treatment effects in a quick and objective manner.

In Vivo Retinal Pigment Epithelium Imaging using Transscleral Optical Imaging in Healthy Eyes

KOWALCZUK, Laura, DORNIER, Rémy, KUNZI, Mathieu, et al.In Vivo Retinal Pigment Epithelium Imaging using Transscleral Optical Imaging in Healthy Eyes. Ophthalmology Science, 2023, vol. 3,

20/03/2023

White paper on clinical use of Cellularis

06/03/2023

Fully automated detection, segmentation, and analysis of in vivo RPE single cells

Caetano dos Santos, F.L., Laforest, T., Künzi, M. et al. Fully automated detection, segmentation, and analysis of in vivo RPE single cells. Eye 35, 1473–1481

20/12/2021

Nature Photonics article on our core technology.

Laforest, T., Künzi, M., Kowalczuk, L. et al. Transscleral optical phase imaging of the human retina. Nat. Photonics 14, 439–445 (2020). https://doi.org/10.1038/s41566-020-0608-y View at publisher

06/03/2020

Frequently asked question

Is Cellularis Discovery available for purchase?

Please contact us directly for any interest in using Cellularis Discovery. We will quickly get back to you.

How do I know where cellular resolution image is taken within the eye?

Cellularis Discovery provides a large field fundus overview image that shows in real-time the area captured with cellular resolution. Moreover, it is storing the position of the fixation target that can be used for a follow-up examination.

Do I need to dilate the patient’s eye for imaging with Cellularis Discovery?

Yes, the minimum pupil size required is 4 mm. We therefore recommend dilating the patient’s eye for optimal quality results.