Advanced ophthalmic camera

We’ve invented a new optical imaging method combining transscleral flood illumination of the retina with adaptive optics (AO-TFI). The method allows the observation of several eye structures at cellular level that are invisible with regular transpupillary illumination. It makes possible the quantitative measurement of structures affected early in diseases, such as retinal pigment epithelium.

Cellular resolution image

RPE cells visualization

Large field fundus overview


Cellularis Discovery provides images that are 10 times more detailed than the standard instruments used in hospitals. Its spectacular precision is achieved while providing a great user experience. Indeed, a quick acquisition time together with manual joystick operation enable simple and familiar examination process for both patient and operator. Moreover, infrared lateral and transpupil illumination is very comfortable for the patient.
Times more precise
Seconds acquisition time
Degrees single cellular image field

Look at tissue details

As opposed to standard instruments, our optical technology allows the observation of microscopic structures in the eye. The ideal tool to catch the first impacts of tissue degenerative processes.

What we can achieve

Cellularis Discovery makes visible important retinal cells and structures, such as retinal pigment epithelium (RPE), retinal nerve fibre layer (rNFL), retinal blood vessels and photoreceptors (PR). These biological structures play key roles in several eye diseases. It is the perfect tool to investigate the retina anatomy and the pathological processes. Research doctors and biotech companies see the potential to better understand eye conditions as well as assessing new treatment effects in a quick and objective manner.


The retinal pigment epithelium cells are suspected to be the first to degenerate in age-related macular degeneration (AMD). The cells appear as small dark spots on our images


The photoreceptors are the cells responsible to capture the light coming in the eye and transform it into electric signal for the brain. They appear as tiny bright dots on our images.


The retinal nerve fiber layer is connecting the retina to the optic disc and optic nerve. The layer is known to degenerate in Glaucoma disease. It appears as stripes made of bundle of axons on our images.



Andrea Cusumano, Francesco Martelli, Marco Lombardo, Fabian D’Apolito, Jacopo Sebastiani, Michele D’Ambrosio, Matteo Guelpa, Benedetto Falsini,Cellular analysis of retinal pigment epithelium and photoreceptors by transscleral optical imaging in inherited macular dystrophies. Investigative Ophthalmology & Visual Science June 2024, Vol.65, 3409.

Mihaela Chitoroaga, Yoan Perez, Nicolas Owlya, Mickael Barbosa, Anna Chiara Nascimbeni, Yannic Pannatier-Schuetz, Daniela Gallo Castro, Aude Ambresin,Adaptive Optics-enhanced dual retinal layer imaging and region reflectivity-based segmentation: unveiling variances in healthy and diseased retina. Investigative Ophthalmology & Visual Science June 2024, Vol.65, 3409.

Laura Kowalczuk, Sohrab Ferdowsi, christophe moser, Irmela Mantel, Francine F. Behar-Cohen, Morphological Analysis of Retinal Pigment Epithelium in Central Serous Chorioretinopathy using Adaptive Optics-Transscleral Flood IlluminationInvestigative Ophthalmology & Visual Science June 2024, Vol.65, 3392.

ARVO Imaging in the Eye Conference 2024, Christian Burri, Martin Zinkernagel, Chantal Dysli, In vivo assessment of human retinal pigment epithelium after selective retina therapy using transscleral flood illumination in combination with adaptive optics.

Leila Sara Eppenberger, Safa Mohanna, Michael A. Thiel and Martin K. Schmid, Exploring the Potential of in vivo Transscleral Optical Imaging by imaging of the retinal “3G” – Retinal Pigment Epithelium, Photoreceptors and Nerve Fiber Layers, Euretina 2022.

Safa Mohanna, Leila S. Eppenberger, Oliver Pfäffli, Lucas M. Bachmann, Michael A. Thiel, Martin K. Schmid Seeing Patterns – First Experiences of Transscleral Optical Imaging in Patients with Age-related Macular Degeneration, Euretina 2022.

Leila Sara Eppenberger, Safa Mohanna, Oliver Pfaeffli, Lucas M. Bachmann, Michael A. Thiel, Martin K. Schmid; First Clinic Experiences of Transscleral Optical Imaging to Study Retinal Pigment Epithelium and Photoreceptor CellsInvest. Ophthalmol. Vis. Sci. 2022;63(7):4460 – F0139. 

Sonja Simon-Zoula, Laura Kowalczuk, R dornier, Mathieu Kunzi, Antonio Iskandar, Zuzana Misutkova, Aurélia Gryczka, Aurélie Navarro, Fanny Jeunet, Irmela Mantel, Francine F Behar-Cohen, Timothé Laforest, Christophe Moser; Human retinal pigment epithelium cells can be imaged in vivo with a novel adaptive optics camera using transscleral illuminationInvest. Ophthalmol. Vis. Sci. 2022;63(7):1056 – F0303. 

Irmela Mantel, Leonidas Solomos, Zuzana Misutkova, Antonio Iskandar, Aurélia Gryczka, Aurélie Navarro, Fanny Jeunet, Laura Kowalczuk, Rémy Dormier, Francine F Behar-Cohen, Christophe Moser; Transscleral optical imaging in non-neovascular age-related macular degenerationInvest. Ophthalmol. Vis. Sci. 2022;63(7):392 – F0430. 

Vishal Govindahari, Laura Kowalczuk, Antonio Iskandar, Zuzana Misutkova, Aurélia Gryczka, Aurélie Navarro, Fanny Jeunet, Irmela Mantel, Christophe Moser, Francine F Behar-Cohen; Transscleral Optical Imaging (TOI) in Central Serous Chorioretinopathy – A novel imaging tool in retinal pigment epithelium visualizationInvest. Ophthalmol. Vis. Sci. 2022;63(7):1011 – F0258. 

Antonio Iskandar, Irmela Mantel, Laura Kowalczuk, Aurelia Gryczka, Aurelie Navarro, Fanny Jeunet, Christophe Moser, Mathieu Kunzi, Francine F Behar-Cohen, Timothe Laforest; Transscleral optical phase imaging in non-neovascular age-related macular degenerationInvest. Ophthalmol. Vis. Sci. 2021;62(8):1919.


Frequently asked question

Please contact us directly for any interest in using Cellularis Discovery. We will quickly get back to you.

Cellularis Discovery provides a large field fundus overview image that shows in real-time the area captured with cellular resolution. Moreover, it is storing the position of the fixation target that can be used for a follow-up examination.

Yes, the minimum pupil size required is 4 mm. We therefore recommend dilating the patient’s eye for optimal quality results.